{"doc_desc":{"title":"Impact d'une chimioth\u00e9rapie n\u00e9oadjuvante combin\u00e9e sur le taux de r\u00e9ponse pathologique compl\u00e8te dans le cancer du sein triple n\u00e9gatif","idno":"FReSH-83199-fr","producers":[{"name":"Tohmas Martin","affiliation":""}]},"study_desc":{"title_statement":{"idno":"FReSH-83199-fr","IDno":{"metadata_no":[{"agency":"","code":""}],"metadata_yes":[{"code":"FReSH","agency":"FReSH"}]},"title":"Impact d'une chimioth\u00e9rapie n\u00e9oadjuvante combin\u00e9e sur le taux de r\u00e9ponse pathologique compl\u00e8te dans le cancer du sein triple n\u00e9gatif","alternate_title":"ICN"},"study_authorization":{"agency":[{"name":"ANSM"},{"name":"CNIL"}]},"authoring_entity":[{"name":"Tohmas;Martin","firstname":"Tohmas","lastname":"Martin","type":"investigator","extlink":[{"title":"ORCID","uri":"","role":"pi id"},{"title":"IdRef","uri":"","role":"pi id"},{"title":"SIREN","uri":"602950206","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/05wz8pk64","role":"organisation id"},{"title":"RNSR","uri":"","role":"labo id"}],"email":"med8@impact-dev.tn","affiliationName":"ABBOTT FRANCE","PILabo":"","isContact":""}],"oth_id":[{"name":"Pharm ;10","firstname":"Pharm ","lastname":"10","type":"contributor","isContact":true,"extlink":[{"title":"ORCID","uri":"","role":"team member id"},{"title":"IdRef","uri":"","role":"team member id"}]},{"name":"ABBVIE","type":"affiliation","teamMemberLabo":"","extlink":[{"title":"SIREN","uri":"750775660","role":"organisation id"},{"title":"RNSR","uri":"","role":"labo id"}]},{"name":"","type":"collaboration"}],"production_statement":{"prod_place":"France Recherche en Sant\u00e9 Humaine (FReSH)","producers":[{"name":"AGENCE DE L ENVIRONNEMENT ET DE LA MAITRISE DE L ENERGIE (ADEME)","role":"sponsor","extlink":[{"title":"SIREN","uri":"385290309","role":"sponsor id"}]}],"funding_agencies":[{"name":"AEPEI (ASSOCIATION POUR L'ETUDE ET LA PREVENTION DES L'ENDOCARDITE INFECTIEUSE)","extlink":[{"title":"SIREN","uri":"428445696"}]}]},"distribution_statement":{"contact":[{"name":"Thomas;MARTIN","lastname":"MARTIN","firstname":"Thomas","type":"contact","email":"med8@impact-dev.tn","affiliationName":"ABBOTT FRANCE","contactPointLabo":"","extlink":[{"title":"SIREN","uri":"602950206","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/05wz8pk64","role":"organisation id"},{"title":"RNSR","uri":"","role":"labo id"}]},{"name":"Pharm ;10","lastname":"10","firstname":"Pharm ","type":"contact","email":"pharm10@impact-dev.tn","affiliationName":"ABBVIE","contactPointLabo":"","extlink":[{"title":"SIREN","uri":"750775660","role":"organisation id"},{"title":"RNSR","uri":"","role":"labo id"}]}]},"study_info":{"keywords":[],"topics":[{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9 : Acc\u00e8s aux soins","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9 : Qualit\u00e9 des soins","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Alimentation","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Hygi\u00e8ne","vocab":"health determinant"},{"topic":"Autre","vocab":"health determinant"},{"topic":"Autres d\u00e9terminants, pr\u00e9cisions","vocab":"other determinant"}],"purpose":"","abstract":"Cette \u00e9tude explore l'efficacit\u00e9 d'une association chimioth\u00e9rapeutique n\u00e9oadjuvante chez des patientes atteintes d'un cancer du sein triple n\u00e9gatif localement avanc\u00e9. L'objectif principal est de d\u00e9terminer le taux de r\u00e9ponse pathologique compl\u00e8te apr\u00e8s traitement, ainsi que d'\u00e9valuer la tol\u00e9rance et les effets secondaires associ\u00e9s. Les patientes sont suivies sur une p\u00e9riode de 24 mois afin d'analyser \u00e9galement la survie sans r\u00e9cidive et la survie globale, avec une attention particuli\u00e8re port\u00e9e aux biomarqueurs pr\u00e9dictifs de r\u00e9ponse au traitement.","coll_dates":[{"start":"2026-09-08"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Ile-de-France','Mayotte','Provence - Alpes - C\u00f4te d'Azur']","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D005260\"\n            },\n            \"value\": \"F\u00e9minin\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D008297\"\n            },\n            \"value\": \"Masculin\"\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"concept\": {\n      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