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<docDscr>
  <citation>
    <titlStmt>
      <titl>Impact of Combined Neoadjuvant Chemotherapy on the Complete Pathological Response Rate in Triple-Negative Breast Cancer</titl>
      <IDNo>FReSH-83199-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="" role="">Tohmas Martin</producer>
    </prodStmt>
    <verStmt>
      <version></version>
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  </citation>
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<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Impact of Combined Neoadjuvant Chemotherapy on the Complete Pathological Response Rate in Triple-Negative Breast Cancer            </titl>
      <altTitl>
                    ICNCP                </altTitl>
      <IDNo agency="FReSH-lang">
                FReSH-83199-en            </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Tohmas Martin                                                <ExtLink title="ORCID" URI="null" role="pi id"/>
                                                                                                                    <ExtLink title="IdRef" URI="null" role="pi id"/>
                                                                                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="ABBOTT FRANCE">
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      <othId affiliation="Pharm 10" type="contributor">
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        <ExtLink title="IdRef" URI="" role="team member id"/>
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      </othId>
      <othId affiliation="" type="collaboration">
                                    </othId>
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    <prodStmt>
      <producer role="sponsor">
                                            AGENCE DE L ENVIRONNEMENT ET DE LA MAITRISE DE L ENERGIE (ADEME)                                            <ExtLink title="SIREN" URI="385290309" role="sponsor id"/>
                    
                </producer>
      <prodPlac>
                France Recherche en Santé Humaine (FReSH)            </prodPlac>
      <fundAg>
                                            AEPEI (ASSOCIATION POUR L&amp;#039;ETUDE ET LA PREVENTION DES L&amp;#039;ENDOCARDITE INFECTIEUSE)                                            <ExtLink title="SIREN" URI="428445696"/>
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="ABBOTT FRANCE" email="med8@impact-dev.tn">
                    Thomas;MARTIN
                                            <ExtLink title="SIREN" URI="602950206" role="organisation id"/>
                                            <ExtLink title="ROR" URI="https://ror.org/05wz8pk64" role="organisation id"/>
                                            <ExtLink title="RNSR" URI="" role="labo id"/>
                                    </contact>
      <contact affiliation="ABBVIE" email="pharm10@impact-dev.tn">
                    Pharm ;10
                                            <ExtLink title="SIREN" URI="750775660" role="organisation id"/>
                                            <ExtLink title="RNSR" URI="" role="labo id"/>
                                    </contact>
      <depDate date="2026-09-19"/>
      <distDate date="2026-09-19"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <studyAuthorization>
    <authorizingAgency>ANSM                </authorizingAgency>
    <authorizingAgency>CNIL                </authorizingAgency>
  </studyAuthorization>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    Free keywords</keyword>
      <topcClas vocab="health determinant">
                        Healthcare system determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants: Access to care                    </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants: Quality of care                    </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants: Eating habits                    </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants: Hygiene                    </topcClas>
      <topcClas vocab="health determinant">
                        Other                    </topcClas>
      <topcClas vocab="other determinant">
                        Other factors, details                    </topcClas>
    </subject>
    <abstract contentType="purpose">null</abstract>
    <abstract contentType="abstract">This study explores the efficacy of a neoadjuvant chemotherapy regimen in patients with locally advanced triple-negative breast cancer. The primary objective is to determine the rate of pathological complete response after treatment, as well as to evaluate tolerability and associated side effects. Patients are followed for a period of 24 months to also analyze recurrence-free survival and overall survival, with particular attention paid to biomarkers predictive of treatment response.</abstract>
    <sumDscr>
      <collDate event="start" date="2026-09-08"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogCover>Ile-de-France</geogCover>
      <geogCover>Mayotte</geogCover>
      <geogCover>Provence - Alpes - Côte d'Azur</geogCover>
      <geogUnit/>
      <anlyUnit>
                Individus            </anlyUnit>
      <universe level="type" clusion="I">General population                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="D005260"/>
                                                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="D008297"/>
                                                    </universe>
      <universe level="age" clusion="I">Young Adult (19 to 24 years)                                                            <concept vocab="MeSH" vocabURI="D055815"/>
                                                    </universe>
      <universe level="age" clusion="I">Adult (25 to 44 years)                                                            <concept vocab="MeSH" vocabURI="D000328"/>
                                                    </universe>
      <universe level="age" clusion="I">Middle Aged (45 to 64 years)                                                            <concept vocab="MeSH" vocabURI="D008875"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged (65 to 79 years)                                                            <concept vocab="MeSH" vocabURI="D000368"/>
                                                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Paraclinical data (non-biological)</dataKind>
      <dataKind>Paraclinical data (non-biological) : Anthropometry</dataKind>
      <dataKind>Paraclinical data (non-biological) : Function testing</dataKind>
      <dataKind>Other</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Primary evaluation (assessment) criterion *</description>
    </developmentActivity>
    <developmentActivity type="secondary evaluation">
                                    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <frequenc>Collection Frequency *</frequenc>
      <sampProc>Probability                                                            <concept vocab="CESSDA" vocabURI="Probability"/>
                                                    </sampProc>
      <sampProc>Non-probability                                                            <concept vocab="CESSDA" vocabURI="Nonprobability"/>
                                                    </sampProc>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Administrative database (employees</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>pupils</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>students</unitType>
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        <frameUnit>
          <unitType>etc.)</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>Disease and death registry</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>Other</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>&lt; 500 individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Converting or copying information into a structured record                                                            <concept vocab="CESSDA" vocabURI="Transcription"/>
                                                    </collMode>
      <collMode>Self-administered questionnaire                                                            <concept vocab="CESSDA" vocabURI="SelfAdministeredQuestionnaire"/>
                                                    </collMode>
      <collMode>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </collMode>
      <sources>
        <sources>
          <sourceCitation>
                                    
                                    
                                                                    </sourceCitation>
        </sources>
      </sources>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <notes subject="observational study method">
                        Cohort study                    </notes>
    <stdyClas>Terminated study</stdyClas>
  </method>
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    <setAvail>
      <avlStatus>
                            Open access                                                            <ExtLink title="COAR" URI="http://purl.org/coar/access_right/c_abf2"/>
                                                    </avlStatus>
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    <useStmt>
      <contact email="med8@impact-dev.tn">Thomas;MARTIN</contact>
    </useStmt>
  </dataAccs>
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<dataDscr>
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